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Article

P329G-engager: a universal mix & match antibody-based adaptor platform for cancer immunotherapy.

mAbs - 1 Dec 2026

Surowka Marlena, Darowski Diana, Hutter-Karakoc Idil, Claus Christina, Ferrara-Koller Claudia, Freimoser-Grundschober Anne, Hofer Thomas, Sam Johannes, Gianotti Reto, Sobieniecki Andrzej, Assisi Denis, Challier John, Leclair Stephane, Mössner Ekkehard, Amann Maria, Umaña Pablo, Klein Christian

Abstract excerpt

Targeting various combinations of tumor antigens and immune cell receptors is of increasing importance in antibody-based cancer immunotherapy. Here, we present a novel modular P329G-engager platform that enables rapid combination of primary tumor-targeting and secondary immune effector antibodies. The platform utilizes two antibodies, each selected from: 1) a set of tumor-targeting adaptor antibodies, bearing...

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Share to Antibodies, Bispecific
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Neoplasm

Share to Cell Line, Tumor

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Source

Open in PubMed Open full text

Identifiers

PMID: 41402230
DOI: 10.1080/19420862.2025.2602993
PMCID: PMC12710928

Genes

CD28
CEACAM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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