Article
Elevated expression of the EZH2 gene in CALR-mutated patients with primary myelofibrosis.
Annals of hematology - 1 Jul 2018
Fan Ni, Tang Yigui, Wu Zhiyuan, Guan Ming, Chen Bobin, Xu Xiaoping, Ma Weizhe, Xu Xiao, Zhang Xinju
Abstract excerpt
Primary myelofibrosis (PMF) is one of the BCR/ABL-negative myeloproliferative neoplasms (MPNs), characterized by the diffuse fibrous hyperproliferation, bone marrow osteosclerosis, extramedullary hematopoiesis, and marked splenomegaly. The patients with PMF have an insidious onset, a long duration of clinical course, and the deteriorated quality of life. It has been reported that the CALR gene 9 exon mutations...
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