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Regulation of Single and Multiple Genes in Bacillus amyloliquefaciens by an Evolution System In Vivo.

ACS synthetic biology - 16 Jan 2026

Jiang Cong, Liu Yanqiu, Han Wenyuan, Zou Dian, Chen Kang, Jiang Xuedeng, Ma Aimin, Wei Xuetuan

Abstract excerpt

With the development of synthetic biology, an evolution system in vivo has been applied to accelerate the construction of cell factories. In this study, an efficient in vivo evolution system was developed for regulation of single and multiple genes in Bacillus amyloliquefaciens. First, the CRISPR/Cas9n-AID base editor was constructed through integration expression of the fused Cas9n protein and activation-induced...

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PMID: 41396964
DOI: 10.1021/acssynbio.5c00480

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C2

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