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Article

Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer's disease.

Scientific reports - 13 Dec 2025

Fu Mingzhou, Tran Thai, Pasaniuc Bogdan, Vossel Keith, Chang Timothy S

Abstract excerpt

Aging populations face increasing incidence of neurological disorders, including Alzheimer's disease (AD) and late-onset epilepsy (LOE), which demonstrate a bidirectional relationship where AD is a risk factor for LOE and LOE is a risk factor for AD. While the APOE gene is a known shared risk factor, comprehensive genetic studies for LOE remain limited. This study employed a multi-task learning framework using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41390778
DOI: 10.1038/s41598-025-32329-8
PMCID: PMC12820071

Genes

APOE
APOC1
BIN1
CLU
TOMM40
TRAPPC6A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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