Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.

doi:10.1016/j.jns.2016.01.022

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Article

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.

Journal of the neurological sciences - 15 Mar 2016

Šerý Omar, Hlinecká Lýdia, Povová Jana, Bonczek Ondřej, Zeman Tomáš, Janout Vladimír, Ambroz Petr, Khan Naim A, Balcar Vladimir J

Abstract excerpt

Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in...

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PMID: 26944113
DOI: 10.1016/j.jns.2016.01.022

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ALOX5

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