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High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2

23 Nov 2023

Abstract excerpt

Mapping mutations and discovering cellular determinants that cause the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce infected cells to form syncytia would facilitate the development of strategies for blocking the formation of such cell-cell fusion. Here we describe high-throughput screening methods based on droplet microfluidics and the size-exclusion selection of...

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PMID: 37996617
DOI: 10.1038/s41551-023-01140-z

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