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Article

Homologous RIG-I–like helicase proteins direct RNAi-mediated antiviral immunity in <i>C. elegans</i> by distinct mechanisms

16 Sept 2013

Abstract excerpt

RNAi-mediated antiviral immunity in Caenorhabditis elegans requires Dicer-related helicase 1 (DRH-1), which encodes the helicase and C-terminal domains homologous to the mammalian retinoic acid inducible gene I (RIG-I)-like helicase (RLH) family of cytosolic immune receptors. Here we show that the antiviral function of DRH-1 requires the RIG-I homologous domains as well as its worm-specific N-terminal domain. We...

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PMID: 24043766
DOI: 10.1073/pnas.1307453110

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