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Article

A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2019

Bronkhorst Alfred W, Vogels Rob, Overheul Gijs J, Pennings Bas, Gausson-Dorey Valérie, Miesen Pascal, van Rij Ronald P

Abstract excerpt

Coevolution of viruses and their hosts may lead to viral strategies to avoid, evade, or suppress antiviral immunity. An example is antiviral RNA interference (RNAi) in insects: the host RNAi machinery processes viral double-stranded RNA into small interfering RNAs (siRNAs) to suppress viral replication, whereas insect viruses encode suppressors of RNAi, many of which inhibit viral small interfering RNA (vsiRNA)...

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Source

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Identifiers

PMID: 31712431
DOI: 10.1073/pnas.1909183116
PMCID: PMC6883776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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