Carvacrol mitigates chronic social isolation stress-induced depressive-like phenotypes via Nrf2-dependent antioxidant defense and downregulation of NF-κB proinflammatory pathway.

Abstract excerpt

Chronic social isolation stress (CSIS) disrupts redox homeostasis and promotes neuroinflammation, contributing to depressive-like behavior. Carvacrol (CV), a monoterpenoid phenol with antioxidants and anti-inflammatory properties, has been studied merely in stress-induced depression. Adult male NMRI mice underwent 6 weeks of CSIS and received CV (10 or 20 mg/kg, i.p.) or a positive control during the final 2...

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• Kelch-Like ECH-Associated Protein 1
• Lipid Peroxidation
• Molecular Docking Simulation
• Monoterpenes