Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior.

doi:10.1073/pnas.2000278117

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Article

Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2020

Nakayama Tomoya, Okimura Kousuke, Shen Jiachen, Guh Ying-Jey, Tamai T Katherine, Shimada Akiko, Minou Souta, Okushi Yuki, Shimmura Tsuyoshi, Furukawa Yuko, Kadofusa Naoya, Sato Ayato, Nishimura Toshiya, Tanaka Minoru, Nakayama Kei, Shiina Nobuyuki, Yamamoto Naoyuki, Loudon Andrew S, Nishiwaki-Ohkawa Taeko, Shinomiya Ai, Nabeshima Toshitaka, Nakane Yusuke, Yoshimura Takashi

Abstract excerpt

Seasonal changes in the environment lead to depression-like behaviors in humans and animals. The underlying mechanisms, however, are unknown. We observed decreased sociability and increased anxiety-like behavior in medaka fish exposed to winter-like conditions. Whole brain metabolomic analysis revealed seasonal changes in 68 metabolites, including neurotransmitters and antioxidants associated with depression....

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PMID: 32277035
DOI: 10.1073/pnas.2000278117
PMCID: PMC7196813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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