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Identification of Novel PI3Kα Inhibitor against Gastric Cancer: QSAR, Molecular Docking, and Molecular Dynamics Simulation based Analysis

2023-12-14

Abstract excerpt

<title>Abstract</title> <p>Gastric cancer (GC) is a malignant tumor with global incidence and death ranking fifth and fourth, respectively. GC patients nevertheless have a poor prognosis despite the effectiveness of more advanced chemotherapy and surgical treatment options. The second most frequently mutated gene in GC is PI3Kalpha, a confirmed oncogene that results in abnormal PI3K/AKT/mTOR signaling, causing en...

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Literature Corpus work
53afc758-557d-50bc-8acc-94e3a0c9e2bd
DOI
10.21203/rs.3.rs-3725094/v1
Open publication

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