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Synonymous Variants of Potential Significance Identified by a 52-Gene Clinical Sequencing Panel in Non-Small Cell Lung Cancer.

Genes, chromosomes & cancer - 1 Feb 2026

Varty Kathleen, MacLean Leah, Itani Doha, Hossain Monowar, Acar Cenk, Michael James, Daigle-Maloney Trisha, Thompson Robert, Johnston Brian, Russell Crispin, Boudreau Jeanette E, Gaston Daniel, Reiman Tony

Abstract excerpt

INTRODUCTION: Next-generation sequencing (NGS) is routinely used for lung cancer genomic profiling to identify known, actionable, non-synonymous driver mutations. Recent findings suggest that synonymous variants may also be cancer drivers. MATERIALS AND METHODS: We analyzed genomic data and clinical outcomes for patients (n = 353) with non-small cell lung cancer (NSCLC) sequenced with the Oncomine Focus 52-gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41711155
DOI: 10.1002/gcc.70111
PMCID: PMC12917934

Genes

ALK
EGFR
FGFR2
FGFR3
KRAS
MYC
NF1
NRAS
PIK3CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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