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Article

Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention.

Diabetes care - 1 Feb 2026

You Lu, Parikh Hemang M, Triolo Taylor M, Ferrat Lauric A, Templeman Erin L, Oram Richard A, Gottlieb Peter A, Rich Stephen S, Onengut-Gumuscu Suna, Steck Andrea K, Krischer Jeffrey, Redondo Maria J

Abstract excerpt

OBJECTIVE: The TrialNet Oral Insulin Prevention Trial TN07 tested oral insulin to prevent stage 3 type 1 diabetes (T1D) in 560 relatives with stage 1 T1D of individuals with T1D. Of the three predefined risk strata, participants in secondary stratum 1 (SS1) (n = 55), characterized by low first-phase insulin release, responded significantly better to oral insulin. We aimed to identify genetic factors associated...

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Share to Administration, Oral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 41364459
DOI: 10.2337/dc25-2006
PMCID: PMC12824796

Genes

CTLA4
GLIS3
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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