Identification and characterization of virtual sub-populations through phenotype-guided filtering. The challenging case of nonidentifiable models in the context of therapeutic evaluation.

Abstract excerpt

The usefulness of mathematical modeling of biological systems and their responses to exogenous products is now well recognized. However, this recognition is marred by problems of unreliability of representations of real populations and predictions of responses to treatments. To remedy this, the generation of virtual populations combined with quantitative systems pharmacology models is increasingly being adopted....

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