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Genetic and structural characterisation of alzheimer's disease associated variants in an Eastern Indian cohort.

Metabolic brain disease - 7 Jul 2026

Sadhukhan Dipanwita, Mukherjee Adreesh, Kamal Izaz Monir, Maitra Shreyosi, Vedeshachaitanya Brahmachari Somnath, Bhattacharyya Bidisha, Biswas Atanu, Chakrabarti Saikat, Biswas Arindam

Abstract excerpt

Alzheimer's disease (AD) shows substantial clinical heterogeneity often caused by genetic variants contributing to both familial and early-onset forms. However, the genetic landscape of AD in the diverse Indian population remains further characterised. To identify probable pathogenic variants associated with AD, representing individuals from Eastern India and to assess their potential structural effects using...

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PMID: 42412289
DOI: 10.1007/s11011-026-01929-2

Genes

APP
ABCA7
PSEN1
SORL1

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