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Article

Predictive Analysis of Brain-Derived Neurotrophic Factor and Apolipoprotein E SNPs in Alzheimer's Pathogenesis.

BioMed research international - 1 Jan 2026

Beliraya Muralidhara Nitheesh, Mallya Sandeep, Prabhu Sudharshan

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) are key regulators of neuronal function and cognitive health. Genetic variations in these genes, particularly nonsynonymous single-nucleotide polymorphisms (nsSNPs), have been linked to Alzheimer's disease (AD). This study employs a computational approach to predict the potential functional impacts of nsSNPs in BDNF and APOE to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42170779
DOI: 10.1155/bmri/3806517
PMCID: PMC13195439

Genes

APOE
BDNF

Variants

rs1048218
rs1048218
rs1048218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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