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Article

Mapping protein variants associated with Alzheimer's disease by mass-spectrometry based de novo sequencing assisted strategy.

Journal of Alzheimer's disease : JAD - 1 Mar 2026

Emekeeva Daria D, Chen Jinfeng, Yang Yang, Yang Jinghua, Gorshkov Mikhail V, Tarasova Irina A

Abstract excerpt

BackgroundAlzheimer's disease (AD) is an incurable neurodegenerative disease with poorly understood pathogenesis. Understanding changes in protein sequences due to amino acid substitutions (AASs) may be important for uncovering molecular mechanisms of this disease.ObjectiveThe study aimed at developing a bioinformatic pipeline for searching AASs in proteomic data and revealing the AD-specific ones, highlighting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41631818
DOI: 10.1177/13872877251414414

Genes

GFAP
HBD
NEFL

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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