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Article

Using genomics to refine pediatric AML risk stratification.

Hematology. American Society of Hematology. Education Program - 5 Dec 2025

Pigazzi Martina, Meshinchi Soheil, Locatelli Franco

Abstract excerpt

In the past 20 years, advances in genomic technologies have greatly improved our understanding of pediatric acute myeloid leukemia (AML). Today, cytogenetic tests can detect structural changes in approximately 75% of cases and remain a main tool for assessing risk. Recent technologies, such as next-generation sequencing, are revealing additional structural alterations (cryptic fusions) and mutations that often...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41348020
DOI: 10.1182/hematology.2025000714
PMCID: PMC12891407

Genes

NPM1
BCL2
CBFA2T3
DNMT3A
FLT3
GLIS2
KMT2A
NSD1
NUP98
TP53
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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