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Article

Tumor characteristics impact prognosis in deficient mismatch repair/microsatellite instability-high localized colorectal cancer-a systematic review and meta-analysis.

JNCI cancer spectrum - 3 Mar 2026

Saqi Ida Kolukisa, Nielsen Amalie Thomsen, Madsen Michael Tvilling, Gögenur Ismail, Orhan Adile, Justesen Tobias Freyberg

Abstract excerpt

BACKGROUND: Deficient mismatch repair (dMMR) and microsatellite instability-high (MSI-H) tumors constitute ∼15% of localized colorectal cancers (CRCs). Prognostic biomarkers such as tumor-infiltrating lymphocytes (TILs) and BRAF and KRAS mutations may guide personalized treatment for these patients, and this systematic review and meta-analysis aimed to evaluate their impact on survival outcomes. METHODS:...

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Identifiers

PMID: 41344844
DOI: 10.1093/jncics/pkaf114
PMCID: PMC12986781

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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