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Article

Tumor characteristics impact prognosis in deficient mismatch repair/microsatellite instability-high localized colorectal cancer-a systematic review and meta-analysis.

JNCI cancer spectrum - 3 Mar 2026

Saqi Ida Kolukisa, Nielsen Amalie Thomsen, Madsen Michael Tvilling, Gögenur Ismail, Orhan Adile, Justesen Tobias Freyberg

Abstract excerpt

BACKGROUND: Deficient mismatch repair (dMMR) and microsatellite instability-high (MSI-H) tumors constitute ∼15% of localized colorectal cancers (CRCs). Prognostic biomarkers such as tumor-infiltrating lymphocytes (TILs) and BRAF and KRAS mutations may guide personalized treatment for these patients, and this systematic review and meta-analysis aimed to evaluate their impact on survival outcomes. METHODS:...

Topics

Humans
Microsatellite Instability
Colorectal Neoplasms
DNA Mismatch Repair
Prognosis
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
Lymphocytes, Tumor-Infiltrating
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease-Free Survival

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 41344844
DOI: 10.1093/jncics/pkaf114
PMCID: PMC12986781

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41344844-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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