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Article

The prognostic and predictive impact of BRAF mutations in deficient mismatch repair/microsatellite instability-high colorectal cancer: systematic review/meta-analysis.

Future oncology (London, England) - 1 Nov 2021

Park Robin, Lopes Laercio, Lee Sunggon, Riano Ivy, Saeed Anwaar

Abstract excerpt

Aims: The authors present a systematic review/meta-analysis of the impact of BRAF mutations on prognosis and immune checkpoint inhibitor (ICI) response in deficient mismatch repair/microsatellite instability-high colorectal cancer. Methods: Hazard ratios for overall survival and odds ratios for objective response rate to ICIs were calculated in BRAF-mutated versus BRAF wild-type patients. Results: After...

Topics

Brain Neoplasms
Colorectal Neoplasms
Humans
Immune Checkpoint Inhibitors
Microsatellite Instability
Mutation
Neoplastic Syndromes, Hereditary
Prognosis
Proto-Oncogene Proteins B-raf

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34323124
DOI: 10.2217/fon-2021-0552

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