Article
Siglec-E deletion alters AT macrophages phenotypes, induces an inflammatory response, and adipogenesis during diet-induced obesity.
International immunopharmacology - 15 Jan 2026
Rakib Ahmed, Al Mamun Md Abdullah, Mandal Mousumi, Yasmen Nelufar, Ofosu-Boateng Malvin, Collier Daniel M, Park Frank, Gyamfi Maxwell A, Jiang Jianxiong, Singh Udai P
Abstract excerpt
Obesity is currently a worldwide health problem, affecting more than 600 million people, and poses a threat to lifestyle and triggers metabolic complications. The infiltration of macrophages into adipose tissue (AT) plays a key role in inducing inflammation and multiple diseases during obesity. Therefore, comprehensive knowledge is required on the crosstalk between adipocytes with resident macrophages in AT to...
Read the complete abstract on PubMedTopics
- Animals
- Macrophages
- Obesity
- Adipogenesis
- Mice
- Diet, High-Fat