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Article

Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization.

Journal of the American Heart Association - 3 Mar 2018

Xie Zulong, Wang Xuedong, Liu Xinxin, Du Huaan, Sun Changbin, Shao Xin, Tian Jiangtian, Gu Xia, Wang Hailong, Tian Jinwei, Yu Bo

Abstract excerpt

BACKGROUND: Obesity is causally associated with atherosclerosis, and adipose tissue (AT)-derived exosomes may be implicated in the metabolic complications of obesity. However, the precise role of AT-exosomes in atherogenesis remains unclear. We herein aimed to assess the effect of AT-exosomes on macrophage foam cell formation and polarization and subsequent atherosclerosis development. METHODS AND RESULTS: Four...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29502100
DOI: 10.1161/JAHA.117.007442
PMCID: PMC5866320

Genes

ABCA1
ABCG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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