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Both single mutation and molecular conjugation on the mutant prevent calcitonin from forming amyloid fibrils.

Biochimie - 1 Mar 2026

Chang Chia-Chi, Sivakumar Govindan, Huang Meng-Chieh, Chen Yun-Hsuan, Wu Shan-Rong, Lai Yun-Ju, Lai Chian-Hui, Tu Ling-Hsien

Abstract excerpt

Human calcitonin (hCT) is a peptide hormone made up of 32 amino acids, produced by the parafollicular cells of the thyroid gland. Its main role is to decrease blood calcium levels by inhibiting osteoclast activity and reducing calcium reabsorption in the kidneys and intestines. This characteristic positions hCT as a potential treatment for bone-related conditions, such as osteoporosis and Paget's disease....

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PMID: 41319951
DOI: 10.1016/j.biochi.2025.11.012

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