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Article

Molecular Insights into the Effects of F16L and F19L Substitutions on the Conformation and Aggregation Dynamics of Human Calcitonin.

Journal of chemical information and modeling - 10 Jun 2024

Huang Fengjuan, Huang Jiahui, Yan Jiajia, Liu Yuying, Lian Jiangfang, Sun Qinxue, Ding Feng, Sun Yunxiang

Abstract excerpt

Human calcitonin (hCT) regulates calcium-phosphorus metabolism, but its amyloid aggregation disrupts physiological activity, increases thyroid carcinoma risk, and hampers its clinical use for bone-related diseases like osteoporosis and Paget's disease. Improving hCT with targeted modifications to mitigate amyloid formation while maintaining its function holds promise as a strategy. Understanding how each residue...

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Identifiers

PMID: 38745385
DOI: 10.1021/acs.jcim.4c00553
PMCID: PMC11349047

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