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Article

Evidence for Wnt/β-Catenin-Activated Rosette-Forming Carcinoma Arising in Rb-Inactivated Bowen Disease.

Journal of cutaneous pathology - 1 Mar 2026

Naharro María José, Rojas Nohelia, Gegúndez Héctor, Monteagudo Carlos

Abstract excerpt

Wnt/β-catenin-activated nonpilomatrical rosette-forming carcinoma is a recently described skin neoplasm with a distinct morphology and pathogenic profile involving mutations in the APC/CTNNB1 and RB1 genes. We report a Wnt/β-catenin-activated, invasive, rosette-forming carcinoma surrounded by Bowen disease on the leg of a 90-year-old woman. Pathogenic mutations in RB1 and APC with allelic frequencies of 83.5% and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41315892
DOI: 10.1111/cup.70024

Genes

APC
CDX2
RB1
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Research trail→

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Evidence for Wnt/β-Catenin-Activated Rosette-Forming Carcinoma Arising in Rb-Inactivated Bowen Disease.PMID 41315892Read ↗

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