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Article

Bidirectional genetic overlap between psychiatric disorders and high-density lipoprotein cholesterol levels.

Lipids in health and disease - 28 Nov 2025

Li Xianjing, Jiang Miaomiao, Zhao Liyang, Chen Zhonghe, Shao Yiqian, Lu Tianlan, Zhang Dai, Li Jun, Wang Lifang

Abstract excerpt

Individuals with psychiatric disorders can show differences in plasma high-density lipoprotein cholesterol (HDL-C), although whether they share a common genomic basis is unclear. This study relied on publicly summarized data from genome-wide association studies for HDL-C and major psychiatric disorders to evaluate shared genetic architecture. Correlation between traits was summarized via linkage disequilibrium...

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Share to Cholesterol, HDL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 41310807
DOI: 10.1186/s12944-025-02797-y
PMCID: PMC12764167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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