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Article

Non-targeted metabolomics revealed novel links between serum metabolites and primary ovarian insufficiency: a Mendelian randomization study.

Frontiers in endocrinology - 1 Jan 2024

Chen Shuang, Zhou Zhaokai, Zhou Zihan, Liu Yu, Sun Shihao, Huang Kai, Yang Qingling, Guo Yihong

Abstract excerpt

Background: Primary ovarian insufficiency (POI) is a common clinical endocrine disorder with a high heterogeneity in both endocrine hormones and etiological phenotypes. However, the etiology of POI remains unclear. Herein, we unraveled the causality of genetically determined metabolites (GDMs) on POI through Mendelian randomization (MR) study with the overarching goal of disclosing underlying mechanisms. Methods:...

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Identifiers

PMID: 38737546
DOI: 10.3389/fendo.2024.1307944
PMCID: PMC11082646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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