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Article

Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype.

PLoS pathogens - 1 Nov 2025

Greenman Joanna H, Chakraborty Shinjini, Moss Lucie, Armstrong Paul C, Kaye Paul M, Hitchcock Ian S, Hewitson James P

Abstract excerpt

Alongside their well-established role in hemostasis, platelets are key modulators of immune cell function. This is particularly the case for macrophages, as platelets can either promote or dampen macrophage activation in a context-specific manner. Whilst the role of platelets in modulating classical (M1) macrophage activation following bacterial challenge is relatively well understood, whether platelets control...

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Identifiers

PMID: 41296814
DOI: 10.1371/journal.ppat.1013732
PMCID: PMC12697973

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TPO

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