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Article

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization.

Molecular cancer - 25 Nov 2025

Ma Chenglong, Liao Ruocen, Chen Xingyu, Cao Qianhua, Deng Xinyue, Dai Zhijun, Dong Chenfang

Abstract excerpt

BACKGROUND: Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its functional mimicry of genetic mutations is unexplored. This study investigates RHOA lactylation at oncogenic hotspots and its role as an "epi-mutation" system....

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Topics

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Share to Carcinogenesis
Share to Enzyme Stability
Share to Lactic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Invasiveness

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Share to rhoA GTP-Binding Protein

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Source

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Identifiers

PMID: 41291745
DOI: 10.1186/s12943-025-02511-7
PMCID: PMC12750741

Genes

RHOA
HDAC3
LDHA
ROCK2
USP9X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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