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Lactylation’s role in bone health and disease: mechanistic insights and therapeutic potential

9 Jun 2025

Abstract excerpt

This article reviews the mechanisms and research progress of lactylation, an emerging post-translational modification (PTM) of proteins, in bone metabolism and related diseases. Lactate-derived lactylation modifies lysine residues on histones, affecting chromatin structure and gene expression. Studies indicate that lactylation plays a significant role in bone metabolism, with mechanisms including the regulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40511385
DOI: 10.7717/peerj.19534

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