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Article

Analysis of perioperative chemotherapy-mediated genomic changes in gastric cancer.

BMC gastroenterology - 25 Nov 2025

Ikegame Ko, Omori Hayato, Hada Masao, Watanabe Hideki, Takano Atsushi, Kimura Ayako, Inoue Masayuki, Furuya Kazushige, Yasutome Michiya, Iimuro Yuji, Nakagomi Hiroshi, Amemiya Kenji, Hirotsu Yosuke, Mochizuki Hitoshi, Omata Masao

Abstract excerpt

BACKGROUND: Surgery remains the mainstay of treatment for advanced gastric cancer, but in recent years perioperative chemotherapy has been administered in an attempt to improve treatment results. The Cancer Genome Atlas (TCGA) has illuminated the molecular landscape of gastric cancer. However, genomic changes before and after perioperative chemotherapy and the associated effects on treatment resistance remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41291443
DOI: 10.1186/s12876-025-04425-6
PMCID: PMC12648925

Genes

CDH1
KRAS
PIK3CA
RNF43
SMAD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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