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Article

Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 β-Barrel.

The journal of physical chemistry. B - 18 Mar 2021

Iwakawa Naoto, Morimoto Daichi, Walinda Erik, Leeb Sarah, Shirakawa Masahiro, Danielsson Jens, Sugase Kenji

Abstract excerpt

Aggregate formation of superoxide dismutase 1 (SOD1) inside motor neurons is known as a major factor in onset of amyotrophic lateral sclerosis. The thermodynamic stability of the SOD1 β-barrel has been shown to decrease in crowded environments such as inside a cell, but it remains unclear how the thermodynamics of crowding-induced protein destabilization relate to SOD1 aggregation. Here we have examined the...

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PMID: 33657322
DOI: 10.1021/acs.jpcb.0c11162

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