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Article

Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2014

Kitamura Akira, Inada Noriko, Kubota Hiroshi, Matsumoto Gen, Kinjo Masataka, Morimoto Richard I, Nagata Kazuhiro

Abstract excerpt

A hallmark of protein conformational disease, exemplified by neurodegenerative disorders, is the expression of misfolded and aggregated proteins. The relationship between protein aggregation and cellular toxicity is complex, and various models of experimental pathophysiology have often yielded conflicting or controversial results. In this study, we examined the biophysical properties of amyotrophic lateral...

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Source

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Identifiers

PMID: 24450587
DOI: 10.1111/gtc.12125
PMCID: PMC4207061

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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