Identification and Computational Analysis of BRCA2 Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer.

doi:10.3390/medsci13040248

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Identification and Computational Analysis of BRCA2 Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer.

Medical sciences (Basel, Switzerland) - 29 Oct 2025

García-Verdín Patricia Montserrat, García-Ortiz José Elías, Garibaldi-Ríos Asbiel Felipe, Dávalos-Rodríguez Ingrid Patricia, Mendoza-Ruvalcaba Sandra Del Carmen, Magaña-Torres María Teresa, Figuera Luis E, Rosales-Reynoso Mónica Alejandra, Tovar-Jácome Cesar de Jesús, Zúñiga-González Guillermo Moisés, Gómez-Meda Belinda Claudia, Torres-Mendoza Blanca Miriam, Villegas-Pacheco Raquel, Gómez-Cerda René, Cárdenas Valdez Julio César, Meza-Chavolla Sergio Osvaldo, Gallegos-Arreola Martha Patricia

Abstract excerpt

BACKGROUND: Breast and ovarian cancers (BC and OC) are prevalent malignancies in women globally, with germline variants in the BRCA2 gene significantly increasing the risk of developing these cancers. Despite extensive studies, the frequency and impact of BRCA2 variants in women from Jalisco, Mexico, remain underexplored. OBJECTIVE: The aim of this study was to identify and characterize BRCA2 gene variants in...

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PMID: 41283249
DOI: 10.3390/medsci13040248
PMCID: PMC12641962

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