Article
Identification and Computational Analysis of BRCA1 Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer.
Medical sciences (Basel, Switzerland) - 1 Aug 2026
Gallegos-Arreola Martha Patricia, Garibaldi-Ríos Asbiel Felipe, Dávalos-Rodríguez Ingrid Patricia, Magaña-Torres María Teresa, Figuera Luis E, Zúñiga-González Guillermo Moisés, Gómez-Meda Belinda Claudia, Torres-Mendoza Blanca Miriam, Villegas-Pacheco Raquel, Gómez-Cerda René, Cárdenas-Valdez Julio César, Meza-Chavolla Sergio Osvaldo, Rosales-Reynoso Mónica Alejandra, Ángeles-Bueno Wenceslao Guillermo, Gómez-Villegas María José, Espinoza Daniela Del Rocío Panduro, García-Ortiz José Elías
Abstract excerpt
BACKGROUND: Breast and ovarian cancer are among the most common neoplasms in women, and germline variants in the BRCA1 gene markedly increase the risk of developing them. Despite existing studies, the frequency and spectrum of BRCA1 variants in women from Jalisco, Mexico, remain underexplored. OBJECTIVE: To identify and characterize BRCA1 variants in a cohort of Mexican women with breast and ovarian cancer, and...
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