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Article

MNMO: discover driver genes from a multi-omics data based-multi-layer network.

Bioinformatics (Oxford, England) - 29 Mar 2025

Deng Zheng, Wu Jingli, Chen Xiaorong, Li Gaoshi, Liu Jiafei, Hu Zhipeng, Li Rongyuan, Deng Wansu

Abstract excerpt

MOTIVATION: Cancer as a public health problem is driven by genomic variations in "cancer driver" genes. The identification of driver genes is critical for the discovery of key biomarkers and the development of personalized therapy. RESULTS: We propose a prediction method MNMO: a multi-layer network model based on multi-omics data. MNMO firstly constructs a dynamically adjusted four-layer network composed of...

Read the complete abstract on PubMed

Topics

Humans
Neoplasms
MicroRNAs
Computational Biology
Genomics
Algorithms
Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Software

Multiomics

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Identifiers

PMID: 40152235
DOI: 10.1093/bioinformatics/btaf134
PMCID: PMC12033032

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