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Article

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

Cancer research - 15 Aug 2017

Hou Panpan, Wu Chao, Wang Yuchen, Qi Rui, Bhavanasi Dheeraj, Zuo Zhixiang, Dos Santos Cedric, Chen Shuliang, Chen Yu, Zheng Hong, Wang Hong, Perl Alexander, Guo Deyin, Huang Jian

Abstract excerpt

Acute myeloid leukemia (AML) is a malignant hematopoietic disease and the most common type of acute leukemia in adults. The mechanisms underlying drug resistance in AML are poorly understood. Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are the most common molecular abnormality in AM...

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Source

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Identifiers

PMID: 28625976
DOI: 10.1158/0008-5472.CAN-16-1627
PMCID: PMC5559306

Genes

FLT3
SPRY3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-28625976-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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