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Article

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

1 Nov 2019

Abstract excerpt

Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (AML), chemorefractory relapses result from the complex interplay between altered genetic, epigenetic and transcriptional states in leukemic cells. Here, we develop an experimental model system using in vitro lineage tracing coupled with exome, transcriptome and in vivo functional readouts to assess the AML...

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Share to Acute Myeloid Leukemia Research
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PMID: 31676777
DOI: 10.1038/s41467-019-12983-z

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