Uncovering pre-sensitizing agents to FLT3 inhibitors in acute myeloid leukemia with ReSisTrace lineage tracing

Abstract excerpt

While FLT3 inhibitors have significantly improved the treatment of aggressive FLT3-mutated acute myeloid leukemia (AML), the emergence of resistance remains as a major challenge. Here, we applied our recently developed single-cell lineage-tracing method ReSisTrace to identify cells that are pre-resistant or pre-sensitive to FLT3 inhibitors midostaurin and quizartinib in FLT3-ITD-positive AML. By comparing the gene...

Topics

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• Benzothiazoles
• Cell Lineage
• fms-Like Tyrosine Kinase 3
• Leukemia, Myeloid, Acute
• Phenylurea Compounds
• Single-Cell Analysis
• Staurosporine
• Xenograft Model Antitumor Assays

Identifiers and source

Literature Corpus work

bb8626d4-3952-5a48-8865-e03e6461692e

DOI

10.1101/2024.10.22.619614