Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of folylpolyglutamate synthase polymorphisms with methotrexate response and toxicity in rheumatoid arthritis: a meta-analysis.

The pharmacogenomics journal - 3 Apr 2026

Lee Young Ho, Song Gwan Gyu

Abstract excerpt

This meta-analysis evaluated the association between FPGS gene polymorphisms (rs10106 (1994A > G) and rs1544105 (2572 C > T)) and methotrexate (MTX) efficacy and toxicity in rheumatoid arthritis (RA). Studies published up to October 2025 were identified through PubMed, Embase, Web of Science, Scopus, and manual searches. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated under various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antirheumatic Agents

Share to Arthritis, Rheumatoid

Share to Methotrexate

Share to Peptide Synthases

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 41932892
DOI: 10.1038/s41397-026-00404-6

Genes

FPGS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of folylpolyglutamate synthase polymorphisms with methotrexate response and toxicity in rheumatoid arthritis: a meta-analysis.PMID 41932892Read ↗

MTX pathway gene variants, erythrocyte methotrexate polyglutamates, and treatment outcomes in rheumatoid arthritis.Semantic proximity Read ↗

Influence of FPGS rs1544105 and GGH rs3758149 Gene Polymorphisms on Methotrexate Pharmacogenetics.Semantic proximity Read ↗

Methotrexate pharmacogenetics in rheumatoid arthritis: a status report.Semantic proximity Read ↗

Using pharmacogenetics to predict methotrexate response in rheumatoid arthritis patients.Semantic proximity Read ↗

Effect of Genetic Polymorphisms in the Folate Pathway on Methotrexate Therapy in Rheumatic DiseasesSemantic proximity Read ↗

Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients.Semantic proximity Read ↗

Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study.Semantic proximity Read ↗

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis.Semantic proximity Read ↗

Factors Underlying Failure of Methotrexate Treatment in Rheumatoid Arthritis: Implications in Personalized CareSemantic proximity Read ↗

The impact of gene polymorphisms on the response of methotrexate-based treatments.Semantic proximity Read ↗

Are gene polymorphisms related to treatment outcomes of methotrexate in patients with rheumatoid arthritis? A systematic review and meta-analysis.Semantic proximity Read ↗

RFC1 80G>A is a genetic determinant of methotrexate efficacy in rheumatoid arthritis: a human genome epidemiologic review and meta-analysis of observational studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.