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Article

Targeted molecular profiling uncovers true ceruminous adenomas with HMGA2::WIF1 and ceruminous syringocystadenoma papilliferum with BRAF V600E.

Virchows Archiv : an international journal of pathology - 1 Feb 2026

Rooper Lisa M, Thompson Lester D R, Sangoi Ankur R, Oliver Dwight, Gagan Jeffrey, Bishop Justin A

Abstract excerpt

Ceruminous adenomas are benign neoplasms that arise from ceruminous glands in the external auditory canal. While these tumors are currently regarded as a single entity, they are divided into three histologically diverse subtypes: ceruminous syringocystadenoma papilliferum, ceruminous pleomorphic adenoma, and ceruminous adenoma not otherwise specified (NOS). Given the similarities of two of these subtypes to other...

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Identifiers

PMID: 41266927
DOI: 10.1007/s00428-025-04256-6

Genes

HMGA2
WIF1
BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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