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Article

GRHL-rearranged sebaceoma: expanding the clinical and morphologic spectrum.

Human pathology - 1 Apr 2026

Dileep Anum, Ko Christine J, LeBlanc Robert E, Panse Gauri G, Cloutier Jeffrey M

Abstract excerpt

Sebaceoma is a benign sebaceous neoplasm with broad architectural variability, and outside of mismatch repair (MMR)-deficient tumors, its molecular features have remained poorly defined. Recent work identified recurrent GRHL1/GRHL2 rearrangements in a subset of sebaceomas, suggesting the presence of a molecularly distinct group. We report three additional sebaceomas harboring RCOR1::GRHL2 fusions identified by...

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Identifiers

PMID: 41580204
DOI: 10.1016/j.humpath.2026.106058

Genes

GRHL2
GRHL1
RCOR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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