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Article

Epigenetic regulation of TGF-β1 signalling in dilative aortopathy of the thoracic ascending aorta

7 Jul 2016

Abstract excerpt

The term 'epigenetics' refers to heritable, reversible DNA or histone modifications that affect gene expression without modifying the DNA sequence. Epigenetic modulation of gene expression also includes the RNA interference mechanism. Epigenetic regulation of gene expression is fundamental during development and throughout life, also playing a central role in disease progression. The transforming growth factor β1...

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PMID: 27389586
DOI: 10.1042/cs20160222

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