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Article

A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.

Archives of general psychiatry - 1 Sept 2009

Ising Marcus, Lucae Susanne, Binder Elisabeth B, Bettecken Thomas, Uhr Manfred, Ripke Stephan, Kohli Martin A, Hennings Johannes M, Horstmann Sonja, Kloiber Stefan, Menke Andreas, Bondy Brigitta, Rupprecht Rainer, Domschke Katharina, Baune Bernhard T, Arolt Volker, Rush A John, Holsboer Florian, Müller-Myhsok Bertram

Abstract excerpt

CONTEXT: The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3 patients does not fully recover even after several treatment trials. Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome. OBJECTIVE: To identify genetic and clinical determinants of antidepressant drug treatment outcome in depression. DESIGN: Genomewide pharmacogenetic...

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Identifiers

PMID: 19736353
DOI: 10.1001/archgenpsychiatry.2009.95
PMCID: PMC4465570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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