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Article

Proliferative Nodule With Unusual Features in a Giant Congenital Melanocytic Nevus.

Pediatric dermatology - 1 Jan 2026

Aparício Martins André, Martins Francisco, Cardoso José Carlos, Calonje Eduardo, Ramos Leonor

Abstract excerpt

We describe a case of a newborn male with an erythematous friable nodule on a dorsolumbar giant congenital melanocytic nevus. Histopathology revealed a spindle cell neoplasm with a high mitotic index, negative for melanocytic markers, suggesting a mesenchymal tumor. However, genetic sequencing identified the NRAS Q16R mutation both in the nodule and underlying congenital nevus, leading to the diagnosis of a...

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Share to NRAS gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41255066
DOI: 10.1111/pde.70086

Genes

NRAS

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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