Article
Next-generation sequencing revealing TP53 mutation as potential genetic driver in dermal deep-seated melanoma arising in giant congenital nevus in adult patients: A unique case report and review of the literature.
Journal of cutaneous pathology - 1 Dec 2020
Ricci Costantino, Ambrosi Francesca, Grillini Marco, Serra Margherita, Melotti Barbara, Gruppioni Elisa, Altimari Annalisa, Fiorentino Michelangelo, Dika Emi, Lambertini Martina, Corti Barbara
Abstract excerpt
Melanoma in giant congenital nevus (M-GCN) is a rare and potentially lethal neoplasm. In children, M-GCN appears as a dermal/deep-seated melanoma (DDM-GCN) with histopathologic features difficult to distinguish from proliferative nodules (PNs-GCN). DDM-GCN in adults is an anecdotal entity and only 8 cases have been described and genetically characterized. We report the first case of DDM-GCN in a 34-year-old man...
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