Using the Reactome Graph Database to generate pathway fingerprints for cancer-related genes, and using the fingerprints to gain insights into cancer, comorbidity, and cancer gene networks.

doi:10.1016/j.compbiolchem.2025.108686

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Using the Reactome Graph Database to generate pathway fingerprints for cancer-related genes, and using the fingerprints to gain insights into cancer, comorbidity, and cancer gene networks.

Computational biology and chemistry - 1 Feb 2026

Iengar Prathima, Venkatraman Prasanna

Abstract excerpt

The Reactome Graph Database, which describes biological processes in 28 top-level pathways and facilitates efficient data- traversal and retrieval, has been used in a novel way to generate pathway fingerprints for 862 cancer driver- and 324 comorbidity-associated- genes; the latter set of genes cause Mendelian Diseases (MDs) which are comorbid with cancer. A pathway fingerprint presents pathway information about...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comorbidity
Share to Databases, Genetic
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Source

Open in PubMed

Identifiers

PMID: 41252800
DOI: 10.1016/j.compbiolchem.2025.108686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.