Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis

27 Oct 2022

Abstract excerpt

BACKGROUND: To achieve elimination of Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is needed. We have developed a CRISPR based diagnostic for HAT using SHERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing) that is readily adaptable to a field-based setting. METHODS: We adapted SHERLOCK for the detection of T. brucei...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Parasitic Diseases Research and Treatment
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36374773
DOI: 10.1016/j.ebiom.2022.104308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African TrypanosomiasisPMID 36374773Read ↗

A CRISPR-based diagnostic tool to survey drug resistance in human African trypanosomiasis.Semantic proximity Read ↗

A next generation CRISPR diagnostic tool to survey drug resistance in Human African TrypanosomiasisSemantic proximity Read ↗

A novel CRISPR-based malaria diagnostic capable of <i>Plasmodium</i> detection, speciation, and drug-resistance genotypingSemantic proximity Read ↗

A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, species differentiation, and drug-resistance genotyping.Semantic proximity Read ↗

Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malariaSemantic proximity Read ↗

Detection of Parasites in the Field: The Ever-Innovating CRISPR/Cas12aSemantic proximity Read ↗

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomiasisSemantic proximity Read ↗

CRISPR-assisted test for Schistosoma haematobiumSemantic proximity Read ↗

TropD-Detector: A CRISPR/LbCas12a-Based system for rapid and sensitive screening of <i>Trypanosoma cruzi</i> in Chagas vectors and reservoirsSemantic proximity Read ↗

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-timeSemantic proximity Read ↗

Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030Semantic proximity Read ↗

Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.