Article

A novel CRISPR-based malaria diagnostic capable of <i>Plasmodium</i> detection, speciation, and drug-resistance genotyping

2020-04-02

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR-based diagnostics are a new class of highly sensitive and specific assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific High-Sensitivity Enzymatic Reporter UnLOCKing, is one such CRISPR-based diagnostic that combines recombinase polymerase pre-amplification, CRISPR-RNA base-pairing, and LwCas13a activity for nucleic acid detection. We developed SHERLOCK...

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Literature Corpus work: 9021dceb-4414-5e88-be63-d9a72c34b249
DOI: 10.1101/2020.04.01.017962

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