Article
Frequency of CYP1A2 polymorphism in beagle dogs.
Drug metabolism letters - 1 Apr 2007
Whiterock Valerie J, Delmonte Terrye A, Hui Lester E, Orcutt Tami L, Sinz Michael W
Abstract excerpt
A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals. These genetic frequencies are significantly different from those previously reported and illustrate that different sources and populations of dogs can have...
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